Role of Hormone receptor status, Ki-67 expression and body mass index in endometrial carcinoma: clinical value and survival

摘要

Background: The most known risk factors for developing endometrial cancer are high estrogen levels and obesity which associated with excessive levels of estrogen. Expression of Ki-67 has independent role on prognosis. Effect of hormone receptor, body mass index (BMI) and Ki-67 on disease free survival in endometrial carcinoma and their association with other clinicopathological features was evaluated in this study. Methods: Fifty-three adult female patients were included in this prospective study with histologically confirmed EC. Those patients treated and followed up at Tanta University Hospitals. Hormone receptor status and ki67 was detected by immunohistochemical exam. Body mass index was calculated at time of presentation. Hormonal status, ki-67 and BMI were studied and compared with other clinicopathological criteria. Survival was assessed and compared by Kaplan-Meier curves and log-rank test. Results: Positive expression of ER and PR was detected in 54.7% and 49.1% of patients respectively and significantly associated with less myometrial invasion, low Ki-67, BMI30kg/m230 kg/m2, was significantly associated with earlier stage and endometrioid type ( P =0.04 and 0.003 respectively). Multivariate Cox regression analysis detected that myometrial invasion, tumor grade and ER expression remained statistically significant with DFS. Conclusion: Our study investigated that different molecular factors such as ER, PR and Ki-67 in addition to obesity, significantly associated with tumor characteristics and survival.