Fabrication of Permeable Tubular Structure from Chemically Modified Chitosan with Anticoagulant Activities for Small Blood Vessel Engineering

摘要

Compared to the raw chitosan, phthalized chitosan exhibited good hemocompatibility (inhibiting fibrinogen adsorption and platelet adhesion), promoted endothelial cell growth and attachment, enhanced solubility, and processibility. Through a wet phase-inversion process, selective permeable tubular constructs of varying sizes, morphology, and properties were fabricated from phthalized chitosan, suggesting its potential as a novel biomaterial for small-diameter vascular engineering. The further research on the smooth muscle cells on the fabricated HFMs is in progress.