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A protective McAb 1B5 influences adherence of C.albicans to human epithelial and endothelial cells

机译:保护性McAb 1B5影响白色念珠菌对人上皮细胞和内皮细胞的粘附

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Recently, we produced a protective McAb-1B5 against Candida albicans, its immunoglobulin isotpyes belong to IgM. The McAb could reconize a cell wall antigen (MW:32KD) in the DTT extract of Candida albicans cell. In this article, McAb 1B5 was used in study of adherence of Candida albicans to human buccal epithelial and umbilical vein endothelia cells to find whether this McAb could influence the adherence or not. Conclusion: the adherence of Candida albicans to epithelial and endothelial cells were suppressed obviously by McAb 1B5, in a dose-dependent manner. So, we suggested that influencing the adherence of Candida albicans to host cell maybe is one of the protective mechanisms of McAb 1B5.
机译:最近,我们生产了一种针对白色念珠菌的保护性McAb-1B5,其免疫球蛋白同型异型体属于IgM。 McAb可以在白色念珠菌DTT提取物中对细胞壁抗原(MW:32KD)进行调和。在本文中,McAb 1B5用于研究白色念珠菌对人颊上皮和脐静脉内皮细胞的粘附性,以发现这种McAb是否可以影响粘附。结论:McAb 1B5以剂量依赖的方式明显抑制了白色念珠菌对上皮和内皮细胞的粘附。因此,我们认为影响白色念珠菌对宿主细胞的粘附可能是McAb 1B5的保护机制之一。

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