Non-Dietary Human Exposure and Risk Assessment: Regulatory Issues

摘要

The assessment of the non-dietary exposure and resultant risk potential to pesticides has been an integral part of the regulatory process in the United States, Canada, and the European Union (EU) for decades. Non-dietary exposure assessments require an understanding of the dermal, inhalation, and incidential oral routes of exposure. This area involves exposures that not only result from the occupational handling of pesticide products, but also re-entry into treated fields, non-occupational exposures to home and school applied pesticides, and potential exposure from applications to individuals not involved in the application, typically referred to as bystander exposure. As we enter the second decade of the 21st century there are significant changes occurring regarding regulatory issues involving non-dietary exposures and risk assessments. These issues include the growing use of the risk assessment process in jurisdictions outside of North America and the EU, the development of newer exposure data and databases, and a re-evaluation of the risk assessment process.