Functional Differences Between the Spatio-temporal Learning Rule (STLR) and Hebb Type (HEBB) in Single Pyramidal Cells in the Hippocampal CA1 Area

摘要

The spatio-temporal learning rule (STLR), proposed as a non-Hebb type by Tsukada et al. (1996, 2005), consists of two distinctive factors; "cooperative plasticity without a postsynaptic spike," and its temporal summaion. On the other hand, Hebb (1949) proposed the idea (HEBB) that synaptic modification is strengthened only if the pre- and post-synaptic elements are activated simultaneously. We have shown, experimentally, that both STLR and HEBB coexist in single pyramidal cells of the hippocampal CA1 area.The functional differences between STLR and HEBB in dendrite (local)-soma (global) interactions in single pyramidal cells of CA1 and the possibility of reinforcement learning were discussed.