Hyperspectral imaging (HIS) is being shown as an emerging modality with a great potential indisease diagnosis and surgical cancer resection. Herein, we evaluate feasibility of the HIS todiscriminate and diagnose colon cancer metastasis in a liver from five hematoxylin and eosinstained histopathological specimens. They were collected from the same patient duringintraoperative frozen section analysis. Cancer and non-cancer spectra along with correspondingspatial maps were estimated from hyperspectral images by means of spectral unmixing. It wasfound that maximal angle between cancer spectra is 1.02 degrees less than minimal angle betweencancer vs. non-cancer spectra. Thus, spectrum angle mapper was used for pixel-based diagnosis ofcancer yielding sensitivity between 81.23% and 97.12%, specificity between 85.85% and 97.3%,and accuracy between 86.85% and 96.92%.
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