In-silico based designing of inhibitors against thevirulence and filamentation of Candida albicans, a common human pathogen

摘要

The common human pathogenic fungus, Candida albicans has gained importance for its role in creating animbalance in the human biome. The majority of metabolic diseases have been caused by epigenetic changes in the bacterial and fungal species inhabiting inside the biome. Also the fungal infections had further aggravated the conditions in immunocompromised people. In the present study the factors contributing to the pathogenicity in C albicans have been highlighted and the combination of transcriptional factors Tec1 and Rfg1 have been targeted. These factors work linearly to induce hypha growth in albicans which brews virulence. We have designed a common ligand which can bind effectively with both factors thus inhibiting the serious fungal infections and damages caused by these.