Co-Enzyme Q10 Encapsulating Liposomes: Physicochemical Characterization and Skin Penetration/Retention Profiles

摘要

The primary objective of the present study was to evaluate the penetration/retention of topically applied liposome formulations containing Coenzyme Q10 (CoQ). The formulated liposomes were also investigated for physicochemical properties such as size, polydispersity index (PDI), entrapment efficiency, size evolution, and storage stability was also investigated. All formulations were prepared with different molar ratios of Phospholipon 85G (PL) and cholesterol (CH) by conventional lipid thin film hydration technique. Molar ratio of CH to PL was varied in the range of 0.25 to 1.50. The formulation LF3 was found to be best in terms of size, polydispersity index (PDI), entrapment efficiency, size evolution.