Catalytic Oxidation of Quinine Using Hydrogen Peroxide with Palladium as Catalyst

摘要

The oxidation of quinine using hydrogen peroxide yielded quinine N-oxide as a major product. In this study, the reaction can be accelerated in the presence of palladium chloride (PdCl2) as catalyst. The trace products, however, were identified as the further oxidation products at quinoline moiety producing N-oxide and the secondary alcohol at C-9 producing the ketone, furthermore the alkene transl°Cation product. The trace products were successfully isolated and characterized by NMR protons and carbons. Purification of the product was performed by column chromatography.