Efficient and Selective Aryl-Nitro Reduction of Pharmaceutical Intermediates

摘要

Hydrogenation of nitro groups to produce anilines is a well-established transformation in organic chemistry and the pharmaceutical industry. However, high pressure hydrogenations can be hazardous at multi-kilo scales and functional group compatibly is often problematic for pharmaceutical intermediates requiring a specialized catalyst. In a continued effort to promote electrochemistry in pharma as a greener and safer alternative, an improved method of electrochemically producing anilines has been achieved. In this presentation, the development of a robust and efficient undivided Aryl-nitro reduction will be discussed.