Effect of different short radius centrifuge rotation regimes on electrolytes concentration and markers of the cardiovascular system in volunteers- subjects

摘要

The necessity of development of the methods and means differing from those currently used for preventing possible disturbances in certain functional systems of the body increases for future long-term manned flights to other planets. One of the solutions for the long-term exposure to microgravity could be the installation on board of manned spacecraft of a short-radius centrifuge (SRC), inducing a periodic gravitational effect on the human body. One of the tasks currently studied in the IBMP ground tests with the participation of volunteers-subjects is the choice of the optimal regimes for creation of artificial gravity on the SRC. Nine healthy male volunteers aged 25-40 participated SRC rotation with three different regimes, with an interval between tests of at least 3 days. The active factor in testing was acceleration of the head-pelvis (+ Gz) direction up to 2.0-2.9 g at the level of feet. The dynamics of markers characterizing the state of the cardiovascular system and water-electrolyte metabolism was studied. The analysis of the dynamics of concentration: aldosterone, brain natriuretic peptide, potassium, sodium and ionized calcium, human big endothelin (1-38) and renin activity in blood plasma and the analysis of cortisol concentration in saliva before and immediately after rotation on the SRC was carried out. Although the further study is needed to better understand the implications of these findings for the use of SRC as a countermeasure in space flights, this study gives an understanding of the directions of ongoing processes of water and electrolyte balance regulation.