Antimicrobial activities by the novel synthetic antimicrobial peptide against multidrug resistance and biofilm forming strains in a guinea pig model

摘要

Membrane-active peptides, including a host of antimicrobials and toxins, have been shown to induce the formation of transmembrane pores. Although the molecular mechanisms by which pore formations occur remain to be thoroughly elucidated, the three mechanisms thus far proposed include the "barrel-stave", "carpet", and "toroidal" models. In the barrel-stave model, peptide helices form a bundle with a central lumen within the membrane, appearing similar to a barrel in which the helical peptides function as the staves [1-5].