Fmoc-beta-Ala-OH and Fmoc-beta-Ala-amino acid-OH:two new impurities in Fmoc-protected amino acid derivatives

摘要

The presence of Fmoc-beta-Ala-Ala-OH in a commercially-produced batch of Fmoc-Ala-OH was first observed in 2002 by our R&D department during the production of one of our drug substances,namely,a proprietary peptide containing more than 20 amino acids,among them Ala at three positions(positions x,y and z).