Optical spectral sensor for the assessment of uric acid kinetics during hemodialysis treatment

摘要

The dual-wavelength direct spectrophotometric method for uric acid determination in effluent dialysate and deep UV LED based optical spectral sensor for non-invasive online hemodialysis monitoring were developed. The time profiles of uric acid concentration in effluent dialysate were recorded for a group of 12 patients and 88 hemodialysis sessions by means of the sensor. The parameters of the double-pool kinetic model for each session were assessed and analyzed. The feasibility of online optical monitoring in the UV region as a useful and convenient tool for the experimental investigation of uric acid kinetics during hemodialysis was demonstrated.