A phylogenetic analysis for gene ITPK1

摘要

Inositol 1,3,4-trisphosphate 5/6 kinase (ITPK1) is a pivotal enzyme in producing IP6, a moleculae that play an essential role in many biochemistry process in mammal cells. In this paper, two phylogenetic trees are constructed based on the mRNA sequences and the protein sequences, respectively. The results indicate that the protein sequences are more conserved than mRNA sequences in primates. Although both plant and animal have an abundant distribution of ITPK1 domain, there exists a great variation in protein sequence between plant and animal. The protein-based tree reflects an evolution orders that is consistent with that of organisms evolution. Z-test of selection indicates that evolution of protein ITPK1 is caused by selection pressure.