Calcium-dependent fMRI using interaction of magnetic nanoparticles and synaptotagmin C2 domains

摘要

Fluctuations in extracellular calcium ions (Ca ) are closely correlated with neural activity because of the influx of Ca2+ into presynaptic neurons during synaptic transmission in the brain. An extracellular calcium probe could therefore become a useful tool for overcoming limitations of conventional functional magnetic resonance imaging (fMRI) readouts based on blood flow.