Supramolecular Polymerization of GroEL Protein and siRNA for 'Artificial Viruses'

摘要

Supramolecular polymerization involving biomolecules such as ribonucleic acid (RNA) and proteins are highly challenging to fabricate, but important to explore the structure and functional features of biomaterials. Typical example is a virus that formed via supramolecular assemblage of bio-tailored capsid protein around RNA, which infect the host cells and deliver their genome into subcellular compartments (cytosol or nucleus).