Chiral Strong Bronsted Acid-Catalyzed Asymmetric Addition Reaction of Azlactones to Styrene Derivatives

摘要

Nucleophilic addition reactions initiated by protonation of olefins with Bronsted acid are one of classical reactions in organic chemistry. Whereas chiral Bronsted acid-catalyzed asymmetric addition reactions of electron rich olefins have been accomplished, that of simple olefins, such as styrene derivatives, still represents a formidable challenge because of their low reactivities. Therefore, the development of more acidic chiral Bronsted acids which facilitate the efficient activation of such olefins is desirable.