FIBROBLAST GROWTH FACTOR-23 IN CANINE CHRONIC KIDNEY DISEASE

摘要

In humans and cats with chronic kidney disease (CKD), fibroblast growth factor-23 (FGF-23) has been associated with disease progression and development of renal secondary hyperparathyroidism (RHPT). In humans, elevations in FGF-23 often precede hyperphosphatemia and RHPT. The objectives of this study were to measure plasma FGF-23 concentrations in healthy dogs and dogs with CKD and to determine its association with serum creatinine, phosphorus, and parathyroid hormone (PTH) concentrations.