Topological microfluidic structures for rapid mixing of emulsions

摘要

A novel use for topological structures inside microfluidic channels is presented. These structures have been successfully utilised to aid in mixing of two water-in-oil emulsions in order to force coalescence, thereby introducing a cross linker into the primary emulsion to form particles. The method has been demonstrated by the manufacture of self-immobilised enzyme particles, which exhibit high activity retention while also producing highly monodisperse particles.