The Effect of Ethanol Extract of Noni (Leaves Morinda citrifolia) on Parasitemia in Balb/c Mice infected with Plasmodium berghei

摘要

Malaria fever is a disease that is still a problem in developing countries. Plasmodium berghei is a facultative intracellular parasite, the immune system that plays a role in the cellular system. Morinda citrifolia is a traditional medicinal plant that contains many active compounds that can reduce the number of malaria Parasitemia. Objective: To prove the effect of ethanol extract morinda citrifolia on the decrease of malaria parasitemia of Balb/c mice infected by Plasmodium berghei. Methods: This type of research was experimental with the design of the post test only control group design in experimental animals, balb/c mice consisting of 24 male mice, divided into 4 groups. (K) was a control group infected with Plasmodium berghei, and the treatment group (P1, P2, P3) were given extract morinda citrifolia with multilevel doses (0.32 mg/kgBW/day, 0.64 mg/kgBW/ day, 1,28 mg/kg BW/day) for 3 days after being infected with Plasmodium berghei as much as 0.1 ml x 10~6. During 4 days given a multilevel dose of noni leaf extract and the 7th day intravenous blood isolation was carried out followed by parasitemia examination. Data were obtained from the calculation of the number of malaria parasitemia decreases in each field of view. Results: The mean decrease in malaria control paristemia was higher than the treatment group (22.17 x 10~6) ± (16.65 x 10~6) with (p = 0.0001). Conclusion: Administration of ethanol extract of Morinda citrifolia can reduce malaria parasitemia in Balb/c mice.