Antioxidant and genoprotective properties of the antidiabetic drug metformin under X-ray irradiation

摘要

The antioxidant and genoprotective properties of the antidiabetic drug metformin have been investigated. The research was performed both in vitro and in vivo under X-ray irradiation. It. was shown that metformin reduced the formation of hydroxyl radicals and hydrogen peroxide in aqueous solutions irradiated with X-rays. The particular features of its influence on the formation of H2O2 were revealed. It has been established that metformin reduced the formation of 8-oxoguanine, a key biomarker of oxidative damage to DNA, in vitro. The effect of metformin on the frequency of micronucleus formation in polychromatic erythrocytes of bone marrow of irradiated mice was investigated. Its genoprotective and radiomimitatory properties at different concentrations and times of application are shown.