Mathematical modeling of drug delivery in tissue cells using electroporation

摘要

Nowadays, electroporation is widely used to deliver drug in different parts of the human body. In electroporation, long time low voltage electric pulses are used to transport drug molecules into the cell through the cell membrane. A mathematical model of drug delivery into the electroporated cells is advocated in the current study which deals with both reversible and irre-versible cells. Furthermore, the model depicts temperature change in the tissue as an outcome of electroporation due to the effect of an electric pulse. This leads to a set of ordinary differential equations and a system of partial differential equations which are solved numerically with appropriate initial and boundary conditions. Drug distribution in both reversible and irreversible cells are illustrated through graphical representations which help in the apprehension of the underlying physical phenomena. Temporal change in the electroporated tissue temperature is also noted analytically.