Digital signal processing techniques for identification of functional unknown elements in ribosomal RNA

摘要

The process of rRNA assembly in mammalian cells starts from the primary 47S transcript and, by a series of cleavages, leads to the production of three rRNAs: 18S, 28S and 5.8S. During this process, the non-coding flanking regions are removed. We have applied a digital signal processing analysis to one of this non-coding region (Internal Transcribed Spacer 1) to evidenciate the presence of putative regulatory sites. The results show that known cleavage sites are detected and also encourage suggestions about other possible regions of interests that might play a role as regulatory site or recognition site.