Cartilage Penetrating Nanocarriers to Provide Sustained Delivery of Disease Modifying Drugs In Post-Traumatic Osteoarthritis

摘要

Osteoarthritis is a debilitating disease of the joint.There are a variety of causes of osteoarthritis a however,one particular etiology,post-traumatic osteoarthritis(PTOA),is of particular clinical interest because it has a biologically and temporally well-defined onset a a traumatic joint injury.There is potential for immediate post-injury intervention with a drug to mitigate the progression of the disease.However,no such disease modifying osteoarthritis drug currently exists.