Modelling Patient's Spontaneous Effort During Controlled Mechanical Ventilation Using Basis Functions

摘要

During mechanical ventilation(MV)of respiratory failure patients,clinicians require real time patient-specific lung condition to set MV treatment.Application of mathematical models to determine patient-specific condition in setting MV is increasingly sought after amongst clinicians.However,when the patient is breathing spontaneously during controlled ventilation modes,estimation of respiratory mechanics becomes erroneous due to presence of patient inspiratory effort.Thus,there is a need to determine patient's respiratory mechanics during the presence of these efforts.This study presents a mathematical expression built on the single compartment model to determine patient respiratory mechanics.The model uses basis function and takes patient inspiratory effort into account.Inspiratory efforts of 1125 cases were simulated to determine the model performance and its stability.The study revealed that the model was capable of estimating asynchronous airway pressure.The model can be potentially useful to simulate any nonlinear airway pressure waveform with spontaneous effort.