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Release kinetics performance of ibuprofen molecule from ordered mesoporous carbon with deferent concentration of drug loading

机译:用不同浓度的药物载荷从有序中孔碳释放离华蛋白分子的动力学性能

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In this study, we present a hard templating route for the synthesis of a high porosity and surface areas of ordered mesoporous carbon. Firstly, silica hard template prepared by self-assembly route using tetraethoxysilane (TEOS) and triblock copolymer Pluronic F127 which is employed as templating directing agents under acidic conditions. By using powder silica template and sucrose directly catalyzed by H_2SO_4 in the synthesis mixture, ordered mesoporous carbon were generated after calcination composite followed by organic removal in the common washing process. Character of the ordered mesoporous carbon was studied by nitrogen adsorption-desorption, scanning electron microscopy and surface analysis techniques. The drug delivery system performance was evaluated in a simulated body fluid after ibuprofen loading process. The present drug release route showed the advantage of being a slow rate of ibuprofen release so that ordered mesoporous carbon can be the new generation carrier material for ibuprofen molecule delivery system.
机译:在这项研究中,我们提出了一种用于合成有序中孔碳的高孔隙率和表面积的硬模板途径。首先,使用四乙氧基硅烷(TEOS)和三嵌段共聚物Pluronic F127通过自组装途径制备的二氧化硅硬模板,其在酸性条件下用作模板引导剂。通过在合成混合物中使用通过H_2SO_4直接催化的粉末二氧化硅模板和蔗糖,在煅烧复合材料后产生有序的介孔碳,然后在普通的洗涤过程中除去有机物。通过氮吸附 - 解吸,扫描电子显微镜和表面分析技术研究了有序介孔碳的特征。在布洛芬加载过程后,在模拟体液中评价药物递送系统性能。本发明的药物释放途径显示了布洛芬释放的慢速速率的优点,因此有序的介孔碳可以是用于布洛芬分子输送系统的新一代载体材料。

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