Ordered mesoporous carbons for ibuprofen drug loading and release behavior

摘要

Ibuprofen (IBU) was selected as model drug and loaded onto ordered mesoporous carbons (OMCs). Effect of the OMCs structures on IBU drug loading and release was studied for the first time. The carbon materials before and after IBU loading were characterized by N2 sorption analysis, small angle X-ray diffraction (XRD) and transmission electron microscopy (TEM). The results showed that the loading of IBU had not greatly changed the basic ordered pore structure of the OMCs. The IBU adsorption process followed the Langmuir adsorption and the adsorbed IBU amount was mainly a function of the specific surface area and pore volume. The two-step release process of a first fast release and then a slower release was observed. The release behavior of IBU was well correlated with time using a simple hyperbolic equation. The pore size was a crucial factor for the release rate of IBU, which increased with the increase of pore size.