磁性有序介孔纳米碳靶向药物载体的制备与控释性能

摘要

药物的靶向控释已成为肿瘤化疗研究的热点.以有序介孔纳米碳球(OMCNs)为基质,先后对其进行磁化、氨基和肼基修饰,最终制得可与抗肿瘤药物盐酸阿霉素(DOX)共价结合的磁靶向药物载体(HMOMCNs).利用场发射扫描电子显微镜、X射线衍射分析仪、热重分析仪、傅里叶变换红外分析仪、紫外-可见分光光度计等分析手段对HMOMCNs进行结构表征和性能评价.结果显示:HMOMCNs的粒径约为100 nm左右,具有丰富的孔道结构,对DOX的最大载药量为529.18 mg·g-1;HMOMCNs对DOX具有pH控释性,随着pH的降低,其累积释药率增加,当pH降至5.5时,10h累积释药率达到最大,最大值为76％.%The controlled release behavior of targeted drug delivery has attracted widespread concern.In this paper,magnetic targeted drug carrier (HMOMCNs),which can covalently bond to anti-cancer drug doxorubicin hydrochloride (DOX),was synthesized from ordered mesoporous carbon nanospheres (OMCNs) through magnetization,amination and hydrazine modification.The structural characterization and performance evaluation of HMOMCNs were carried out by field emission scanning electron microscopy,X-ray diffraction analyzer,thermogravimetric analyzer,Fourier transformation infrared spectroscopy and ultravioletvisible spectrophotometer.The results showed that the HMOMCNs had a particle size of about 100 nm with good ordered mesoporous structure,and the maximum drug loading capacity was 529.18 mg · g-1.The release of DOX from HMONCNs can be controlled by pH values.With the decrease of the pH value,the cumulative release rate increased.When pH was 5.5,the cumulative release rate was 76％ and reached the equilibrium for about 10 h.