Disease Candidate Gene Identification and Gene Regulatory Network Building Through Medical Literature Mining

摘要

Finding key genes associated with diseases is an essential problem of disease diagnosis and treatment, and drug design. Bioinformatics takes advantage of computer technology to analyze biomedical data to help finding the information about these genes. Biomedical literatures, which consists of original experimental data and results, are attracting more attention from bio-informatics researchers because literature mining technology can extract knowledge more efficiently. This paper designs an algorithm to estimate the association degree between genes according to their co-citations in biomedical literatures from PubMed database, and to further predict the causative genes associated with a disease. The paper also uses hierarchical clustering algorithm to build a specific genes regulation network. Experiments on uterine cancer shows that the proposed algorithm can identify pathogenic genes of uterine cancer accurately and rapidly.