Anti-Proliferative Activity of Benzamide Analogs in A549 Tumor Cells in Vitro

摘要

Objective: To determine the antitumor activity of five benzamide derivatives with similar structure in A549 tumor cells. Methods: Cytotoxicity of the compounds in A549 tumor cells were monitored through an xCELLigence Real-Time Cell Analysis System. Results: Four benzamide analogs inhibited the growth of A549 tumor cells in a dose- and time-dependent manner. Conclusion: Four benzamide derivatives exhibited antiproliferative activity against A549 tumor cells in vitro and could be further developed in preclinical studies as therapeutic agents for non small cell lung cancer.