Study on Osteopontin and Its Clinical Application to Ovarian Cancer

摘要

Osteopontin (OPN) is a kind of phosphorylated acidic glycoprotein, human beings' osteoclasts, macrophages, T cells, and vascular smooth muscle cells can secrete OPN, the gene is located on chromosome 4q13. OPN has a function of adhesion to protein, which can be combined with CD_(44), integrin α_vβ_3 and α_vβ_5, OPN is also involved in bone remodeling, the formation of new blood vessel and the reflection of inflammation. OPN can play the synergistic function in tumor metastasis. In this paper, it takes the introduction of biological function of OPN. As for the aspect of early diagnosis of ovarian cancer and prognosis monitoring, it can be used as the supplement of CA_(125) and markers of other cytokines.