Formulation and Physicochemical Evaluation of Topical Preparations Containing Extract of Clerodendrum disparifolium

摘要

Clerodendrum disparifolium is a Thai herbal medicine, which is used for the treatment of insect bites and sting reactions by applying finely crushed leaves to the inflamed area. However, this usage is inconvenient. The study aimed to develop gel- and cream-based formulations containing 0.5 %w/v of C. disparifolium extract, and evaluate their physicochemical properties. Different topical formulations were prepared using Carbopol 934 for gels and stearic acid for creams by varying their concentrations. The results showed that gel-based formulation containing Carbopol 934 in the range of 0.5-1.0 %w/w had good appearance, appropriate spreadability (7.30-8.70 cm) and viscosity (33,100-68,920 centipoise (cps)). The pH of gel-based formulation ranged from 6.01 to 6.11. For cream-based formulation containing 10-12 % w/w of stearic acid exhibited good physicochemical characteristics. The spreadability, viscosity and pH were 5.00-5.50 cm, 110,050-174,900 cps and 6.03-6.08, respectively. The results provided the suitable formulations, which should be continuously developed for large-scale pharmaceutical production.