Nonwoven Polylactide Scaffolds Obtained by Solution Blow Spinning and the In Vitro Degradation Dynamics

摘要

The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.