In India, arsenic poisoning in groundwater in Gangetic basin, especially the districts adjoining the Ganges river, right from Eastern Uttar Pradesh, Bihar to West Bengal are the major problem of concern and where major health related problems are arising. To combat the present problem and because there are no antidotes against arsenic poisoning, a pre-clinical study on Charles foster rats was done. Sodium arsenite was administered to the rats for 60 days and upon this arsenic pretreated rats, Withania somnifera and Pteris longifolia plant extracts of Himalayan sub-region were selected and administered for 45 days to study the antidote effects. In in-vivo conditions, these plants played the vital role to combat the arsenic induced toxicity completely proving to be the best antidote. The plants not only eliminated the effects of arsenic but also reversed the normal physiological activity in the animal, having the best antidote activity against arsenic induced toxicity.
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