The effect of ultrasound wave on levothyroxine release from chitosan nanoparticles

摘要

A nanoparticle polymer has been developed as a potential platform for drug delivery. Chitosan nanoparticles were prepared with tripolyphosphate (TPP) by the ionic crosslinking method. The particle size of chitosan nanoparticles was in the range of 190-250 nm and encapsulation efficiencies of levothyroxine were 85%. The particle size was determined by photon correlation spectroscopy (PCS). Shape and surface morphology were determined by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). They revealed fairly spherical shape of nanoparticles. A non-invasive way to deliver drugs to the deepest parts of the human body is ultrasound. To study how ultrasound causes levothyroxine to be released from chitosan nanoparticles, cumulative release was examined, In this report, we explore the effect of ultrasound and tripolyphosphate (TPP) concentration on release behavior of levothyroxine from chitosan nanoparticles. The drug release from chitosan nanoparticles was enhanced using the ultrasound wave