Chemiluminescence enhancement effect for the determination of acetaminophen with the catalysis of Manganese Deuteroporphyrin (Mn(IE)DP)

摘要

It is found that Manganese Deuteroporphyrin (Mn(E)DP) can greatly enhance the chemiluminescence intensity of luminol-hydrogen peroxide system in alkaline conditions. Basing on that fact a flow injection chemiluminescence (CL) method has been developed for the determination of acetaminophen. With the peak height as a quantitative parameter applying optimum conditions, the relative CL intensity was linear with acetaminophen concentration in the range of 1.0×10~(-9)~1.0×10~(-7) g/mL with a detection limit of 2.8×10~(-10) g/mL. The relative standard deviation (RSD) was 2.7% for 2.0 × 10~(-8) g/mL acetaminophen (n = 11). The proposed method held low detection limit and was successfully applied to determination of acetaminophen in pharmaceutical preparations.