Glycemic Index: Nano-Considerations and Impact in Rat Model of Type 2 Diabetes

摘要

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose level and abnormalities in carbohydrate, protein and fat metabolism. The resulting hyperglycemia may lead to irreversible damage, dysfunction and failure of various organs. The objective of this study was to investigate the effects of low, medium and high glycemic index (GI) diets on normal as well as diabetic rats. The three diets were fed to the rats and the biochemical nano-variables and organ histology assessed at the end of the study (90 days). Our findings suggest that it may be possible to improve glycemic control, insulin secretion and histoarchitecture of pancreatic islets via consumption of low and medium GI diets.