Molecular imprinted poly(ethyleneco-vinyl alcohol) nanofibers electrospun on gold electrodes for impedimetric creatinine sensing

摘要

In this work, a biomimetic sensor elaborated by direct electrospinning of molecular imprinted poly(ethylene co-vinyl alcohol) (EVOH) onto gold electrodes was proposed for impedimetric creatinine detection. Dimethylsulfoxyde (DMSO) was selected as polymer solvent and creatinine (1% wt) was used as template. In the optimal conditions of fabrication (20% wt EVOH, electrical voltage: 20 kV, collection distance: 30 cm), the sensor response was proportional to log[creatinine concentration] in the 1 fg.L-1-1 μg.L-1 range. We also showed that the sensor could be reused at least three times and that the response of the non imprinted polymer control sensor, prepared the same way but in absence of creatinine, was very low.