The synthesis of the amphiphilic triblock cationic copolymer mPEG-PCL-PDMAEMA the synthesis and Its impact study on the load and transfected of siRNA

摘要

Polyphosphate is a biocompatible, modified and functionalized biodegradable polymer. It has a broad application prospects in the field of medical biomaterials. It is an excellent drug carrier material. In this essay, through the open-loop and ATRP polymerization, it synthesizes biodegradable amphiphilic triblock copolymer PEG-PCL-PDMAEMA. Composition and structure of the polymer is Characterized by ~1H NMR and IR In this essay. This essay also studies that the polymer in water can be self-assembled to form a stable nanoparticles; The polymer micelle can form composite particles with siRNA, This essay also studies the load and transfection of the polymer micelles on siRNA.