The synthesis of atorvastatin intermediates

摘要

Adjust the dose of related synthetic method through the experiment, in order to improve the efficiency of the synthesis of intermediates. When adding catalyst 1.8 g, the product yield up to 63.11%; Adding 30g anhydrous ethanol yield up to 61.45%. different materials for the amount of drug income atorvastatin calcium middle size is different, the preparation should be select best dose.