Image-guided prostate sectioning supporting registration of gradedcancerous foci from digital histopathology images to in vivo MRI:An interactive 3D visualization tool

摘要

Personalized treatment of prostate cancer would be enhanced by an assessment of cancer stage and grade from imaging, the validation of which requires the accurate co-registration of in vivo images with a gold standard for stage and grade established by histopathology. We present a visualization tool supporting an image-guided approach enabling the acquisition of histopathology images parallel to the in vivo imaging planes, simplifying this registration. This tool decreases imaging-to-specimen landmark alignment error by 62%, and decreases the time required to mark the slicing plane on the specimen by 47%. Preliminary results from our method demonstrate the alignment of regions suspicious for. cancer on T2w MRI with confirmed cancer foci on histopathology, and we calculate a sub-millimeter in-plane target registration error.