Preparation of the Microsphere-sized Poly(N-isopropylacrylamide) Hydrogel Dispersed in Polyvinyl aicohoi) Matrix and its Thermo-responsive Releasing Behavior

摘要

A novel thermo-responsive microsphere-sized poly(N-isopropylacrylamide) (PNIPAm) composite hydrogels were prepared by gelation of poly(vinyl alcohol) (PVA) solution containing ultra-fine CaCO_3, then treated with 2wt% glutaraldehyde solution, sequencely with HC1 acid, and PVA matrix with microsphere-sized pores obtained. The internal pores of the dry PVA matrix were filled with PNIPAm hydrogels to give a thermo-responsive composite hydrogels for drug carrier. The composite hydrogel was characterized via scanning electron microscopy (SEM), temperature dependence of equilibrium swelling ratio in water of the composite hydrogels was also investigated. Rhodamine B (RB) was loaded to the composite hydrogels for release study.