Structural modification is still a popular and important route in the forest chemical field for finding novel dehydroabietylamine derivatives with more potential bioactivities and broad bioactive spectra. In this work, a series of dehydroabietylamine derivatives containing tricyclic diterpene structure were synthesized through oxidation in the 7 position of ring B and nitrification in the 12 position of ring C using dehydroabietylamine as raw materials. Chromium trioxide-acetic acid was used as oxidizing reagent and copper nitrate-acetic anhydride was used as nitrating reagent in the synthetic process. Structures of the synthesized compounds were confirmed by IR, NMR and MS. The cytotoxicity of these compounds against PC-3(human prostate carcinoma cell line) and Hey-1B(human ovarian carcinoma cell line) cancer cells by MTT assay were investigated. The results demonstrated that some of the synthesized compounds exhibited somewhat antitumor activities. The information obtained from this study may be useful for the design of novel chemotherapeutic drugs. Additional pharmacology research work is still in progress.
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