The Genome-wide survey of MicroRNA and Transcription Factor-NF-κB regulatory network from Bioinformatics

摘要

@@MicroRNAs (miRNAs) are post-transcriptional regulators which bind to complementary sequences in the three prime untranslated regions(3' UTRs) of target messenger RNA transcripts (mRNAs). Nuclear factor kB (NF-kB) is a nuclear transcription factor that regulates expression of a large number of genes, acting at the transcriptional level. MicroRNAs and NF-kB are closely related to and may regulate each other in theory. MicroRNAs which transcript from the genome would regulated by the NF-kB, which is a typical and widely functioned family of Transcription Factors (TFs);and on the other hand, NF-kB might also be regulated by the microRNAs when its protein coding gene transcripts from the DNA to mRNA, which is the