Genome-Wide Survey of MicroRNA-Transcription Factor Rel/NF-kB Feed-Forward Regulatory Circuits in Human

摘要

In this paper, we described a computational framework to survey the genome wide microRNA (miRNA)-Rel/NF-kB feed-forward regulatory circuits in human. We first searched for human microRNAs with the potential to regulate Rel/NF-KB factors and 605 human microRNAs with functional targets were found in the 3'UTR of Rel/NF-kB genes. Among these 605 predicted microRNAs, 59 microRNAs are evolutionarily conserved between species. We also searched Rel/NF-KB factors that could regulate the expression of human microRNAs. Only 5 sites were identified in the promoter region of human microRNAs, which have the potential to be bound by Rel/NF-KB transcription factors. Accordingly, we proposed two microRNA-Rel/NF-KB feed-forward regulatory circuits, NFKBIA/NF-KB/hsa-mir-196b and Rel/NF-KB/hsa-mir-219-1 in human genome. The identification of Rel/NF-KB and microRNA feed-forward regulatory circuits will help us better to understand the underlying genetic basis of some human cancer.