Fabrication and Characterization of Shellac/2-isopropyl-5-methylphenol Composite Film Patch: Physical and Antimicrobial Properties

摘要

The purpose of this study was to evaluate the physicochemical properties and antimicrobial activity of shellac/2-isopropyl-5-methylphenol composite film patch. 2SHL was applied as a matrix film forming agent for antimicrobial film patch. The samples of IPMP loaded within SHL were prepared in a free film by the casting method. The SHL/IPMP composite film patch was characterized on the physicochemical properties such as: FTIR spectroscopy, X-ray diffraction and mechanical properties. Antimicrobial property was assessed against Staphylococcus aureus and E.coli. The results demonstrated that all films were easily prepared. However, the mechanical properties, XRD and FT-IR of composite film patch were dependent on the composition of blending film while the melting and solubility of film showed no change. The % elongation of the films was increased as the fraction of IPMP increased to 20%, resulting in more flexibility of shellac. The composite film could be formed by the hydrogen bonds, giving the change in physicochemical properties of films. These results were supported by the change in FT-IR and XRD pattern of composite film. The SHL/IPMP composite films exhibited the inhibition zone at 5% concentration of IPMP or more concentration. The diameter of inhibition zone was increased as increasing the percentage of IPMP. The result suggested that antimicrobial SHL/IPMP composite film patch could be achieved. In conclusion, shellac could be a promising polymer for fabrication of antimicrobial film patch, contributing to the widely used as medical products for wound dressing.