Genetic sample sizes in otitis media: Large cohorts are needed to discover susceptibility loci

摘要

Epidemiological studies have shown that recurrent or persistent otitis media has high heritability. The speed and economy of genetic interrogation has fallen tremendously. However our understanding of the genetic architecture of disease has progressed, and for common disorders is thought to be complex and poly genie. In the future large sample sizes, with international collaborative effort, will be needed to ensure adequately powered interrogation of the genetic basis of middle ear inflammation.