Gene Regulatory Network Reconstruction of P38 MAPK Pathway Using Ordinary Differential Equation with Linear Regression Analysis

摘要

P38 MAPK is one of the most important central regulatory proteins that can respond extra environmental stresses. It can activate or inhibit many other genes, which can lead some disease, such as cancers or inflammations etc. We proposed a new differential equation model using linear regression analysis to calculate the weight values of the Genetic Regulatory Networks to simulate the P38 MAPK pathway in Genetic level. The results of the network are reasonable. We can investigate the P38 MAPK pathway some extra hypotheses from the result model, and provide biologists optimal designs for further experiments of disease researches.