Ozone Therapy in Diabetes: a Preclinical and Clinical Study

摘要

In Diabetes, an increase of reactive oxygen species (ROS) plays an important role in diabetic complications. In this study, we evaluate ozone efficacy in an animal model using streptozotocin as a diabetic inductor and in a clinical trial with type 2 diabetic patients suffering of ulcers of the feet and lower extremities in comparison with antibiotic therapy. In both studies, ozone treatment improved glycemic control and prevented oxidative stress, not occurring in the antibiotic group. In the animal model, ozone treatment improved pancreas integrity. The length of hospitalization decreased in patients treated with ozone with regard to the antibiotic group, with less number of amputations. Ozone therapy could be a future alternative in the therapy of diabetes and its complications.